H01
Covers both ADH1B and ALDH2 polymorphisms associated with alcohol metabolism.
Alcohol Metabolism
Alcohol Metabolism Genetic Testing (ADH1B & ALDH2)
Genotyping of key ADH1B and ALDH2 variants to help understand individual differences in alcohol metabolism and associated health risks.
H02
Supports assessment of alcohol metabolism profiles and genetic risk insights.
H03
Suitable for personalized health management and population screening programs.
Product Overview
Alcohol metabolism is largely determined by genetic variations in ADH1B and ALDH2. These genes influence how efficiently ethanol and acetaldehyde are processed, contributing to differences in alcohol tolerance and related health outcomes.
- ADH1B affects the speed of ethanol metabolism.
- ALDH2 influences acetaldehyde clearance and alcohol sensitivity.
- Combined analysis of ADH1B and ALDH2 provides a more complete understanding of individual alcohol metabolism characteristics.
Sample Report Matrix
ADH1B (Ethanol metabolism)ALDH2 (Acetaldehyde metabolism) | TT (Fast) | TC (Medium) | CC (Slow) |
|---|---|---|---|
AA (Slow) | |||
GA (Medium) | |||
GG (Fast) |
*Based on genotyping results, the 9 combinations from these two genes are grouped into 5 alcohol-metabolism grades for reference. Higher grade indicates stronger alcohol tolerance.
Result Interpretation
Name | Test Result | Interpretation |
|---|---|---|
ADH1B Gene | TT/TC/CC | TT: Common genotype. Higher ADH1B activity is associated with faster conversion of ethanol to acetaldehyde. TC: Heterozygous genotype. Intermediate ADH1B activity and ethanol metabolism rate. CC: Homozygous genotype. Lower ADH1B activity and slower conversion of ethanol to acetaldehyde. |
ALDH2 Gene | GG/GA/AA | GG: Common genotype. Normal ALDH2 activity enables efficient conversion of acetaldehyde to acetate. Alcohol-related flushing and discomfort are generally less likely. GA: Heterozygous genotype. Reduced ALDH2 activity may lead to slower acetaldehyde clearance and increased likelihood of flushing, palpitations, or nausea after alcohol consumption. AA: Homozygous genotype. Markedly reduced or absent ALDH2 activity may result in poor acetaldehyde clearance and a higher likelihood of alcohol-related flushing and discomfort. |
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